Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dysferlinopathy Promotes an Intramuscle Expansion of Macrophages with a Cyto-Destructive Phenotype.

The American journal of pathology - 1 Jun 2017

Baek Jea-Hyun, Many Gina M, Evesson Frances J, Kelley Vicki R

Abstract excerpt

Dysferlinopathies are a group of muscular dystrophies resulting from a genetic deficiency in Dysf. Macrophages, highly plastic cells that mediate tissue repair and destruction, are prominent within dystrophic skeletal muscles of dysferlinopathy patients. We hypothesized that Dysf-deficient muscle promotes recruitment, proliferation, and skewing of macrophages toward a cyto-destructive phenotype in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Communication
Share to Cell Count
Share to Cell Death

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dysferlin

Share to Monocytes

Share to Muscle Fibers, Skeletal

Share to Muscular Dystrophies, Limb-Girdle

Share to Necrosis

Source

Identifiers

PMID: 28412297
DOI: 10.1016/j.ajpath.2017.02.011

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dysferlinopathy Promotes an Intramuscle Expansion of Macrophages with a Cyto-Destructive Phenotype.PMID 28412297Read ↗

Age-dependent Dysferlin Accumulation in Macrophages Promotes STAT1 Activation via Calcium Influx, Impairing MyogenesisSemantic proximity Read ↗

Myogenesis in dysferlin-deficient myoblasts is inhibited by an intrinsic inflammatory response.Semantic proximity Read ↗

Single-cell and spatial transcriptomics identify a macrophage population associated with skeletal muscle fibrosisSemantic proximity Read ↗

Single-cell and spatial transcriptomics identify a macrophage population associated with skeletal muscle fibrosisSemantic proximity Read ↗

Genetic ablation of complement C3 attenuates muscle pathology in dysferlin-deficient miceSemantic proximity Read ↗

Fibroadipogenic progenitors are responsible for muscle loss in limb girdle muscular dystrophy 2BSemantic proximity Read ↗

Dysferlin regulates cell adhesion in human monocytes.Semantic proximity Read ↗

Dysferlin and Animal Models for DysferlinopathySemantic proximity Read ↗

Attenuated muscle regeneration is a key factor in dysferlin-deficient muscular dystrophySemantic proximity Read ↗

Muscular dystrophy in dysferlin-deficient mouse models.Semantic proximity Read ↗

Cripto shapes macrophage plasticity and restricts EndMT in injured and diseased skeletal muscleSemantic proximity Read ↗

Early pathological signs in young <i> dysf <sup>−/−</sup> </i> mice are improved by halofuginoneSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.