Early pathological signs in young <i> dysf ^−/− </i> mice are improved by halofuginone

Abstract excerpt

Dysferlinopathies are a non-lethal group of late-onset muscular dystrophies. Here, we evaluated the fusion ability of primary myoblasts from young dysf −/− mice and the muscle histopathology prior to, and during early stages of disease onset. The ability of primary myoblasts of 5-weekold dysf −/− mice to form large myotubes was delayed compared to their wild-type counterparts, as evaluated by scanning electron...

Topics

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• Adipose Tissue and Metabolism
• Disease Models, Animal
• Drosophila
• Mice
• Muscle Physiology and Disorders
• Muscle, Skeletal
• Mutation
• Neurogenetic and Muscular Disorders Research

Identifiers and source

Literature Corpus work

266aa803-575f-520f-97f5-833e0a7ba406

DOI

10.1101/762732