Article
Dysferlin regulates cell adhesion in human monocytes.
The Journal of biological chemistry - 17 May 2013
de Morrée Antoine, Flix Bàrbara, Bagaric Ivana, Wang Jun, van den Boogaard Marlinde, Grand Moursel Laure, Frants Rune R, Illa Isabel, Gallardo Eduard, Toes Rene, van der Maarel Silvère M
Abstract excerpt
Dysferlin is mutated in a group of muscular dystrophies commonly referred to as dysferlinopathies. It is highly expressed in skeletal muscle, where it is important for sarcolemmal maintenance. Recent studies show that dysferlin is also expressed in monocytes. Moreover, muscle of dysferlinopathy patients is characterized by massive immune cell infiltrates, and dysferlin-negative monocytes were shown to be more...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.