Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

<scp>DNA</scp> damage and senescence in osteoprogenitors expressing Osx1 may cause their decrease with age

12 Apr 2017

Abstract excerpt

Summary Age‐related bone loss in mice results from a decrease in bone formation and an increase in cortical bone resorption. The former is accounted by a decrease in the number of postmitotic osteoblasts which synthesize the bone matrix and is thought to be the consequence of age‐dependent changes in mesenchymal osteoblast progenitors. However, there are no specific markers for these progenitors, and conclusions...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Metabolism and Diseases
Share to Epigenetics and DNA Methylation
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28401730
DOI: 10.1111/acel.12597

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

<scp>DNA</scp> damage and senescence in osteoprogenitors expressing Osx1 may cause their decrease with agePMID 28401730Read ↗

Identification of Senescent Cells in the Bone Microenvironment.Semantic proximity Read ↗

Skeletal Aging and Osteoporosis: Mechanisms and TherapeuticsSemantic proximity Read ↗

Premature aging of skeletal stem/progenitor cells rather than osteoblasts causes bone loss with decreased mechanosensationSemantic proximity Read ↗

Cells derived from young bone marrow alleviate renal aging.Semantic proximity Read ↗

Hypoxia-inducible factor-2α mediates senescence-associated intrinsic mechanisms of age-related bone loss.Semantic proximity Read ↗

Zoledronate Attenuates Accumulation of DNA Damage in Mesenchymal Stem Cells and Protects Their FunctionSemantic proximity Read ↗

CpG Methylation of Receptor Activator NF-κB (RANK) Gene Promoter Region Delineates Senescence-Related Decrease of RANK Gene ExpressionSemantic proximity Read ↗

Loss of the Osteogenic Differentiation Potential during Senescence Is Limited to Bone Progenitor Cells and Is Dependent on p53Semantic proximity Read ↗

Elimination of senescent osteoclast progenitors has no effect on the age‐associated loss of bone mass in miceSemantic proximity Read ↗

Defects in telomere maintenance molecules impair osteoblast differentiation and promote osteoporosisSemantic proximity Read ↗

Cellular senescence by loss of <i>Men1</i> in osteoblasts is critical for age‐related osteoporosisSemantic proximity Read ↗

Tgfbr2 is required in osterix expressing cells for postnatal skeletal development.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.