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Skeletal Aging and Osteoporosis: Mechanisms and Therapeutics

29 Mar 2021

Abstract excerpt

Bone is a dynamic organ maintained by tightly regulated mechanisms. With old age, bone homeostasis, which is maintained by an intricate balance between bone formation and bone resorption, undergoes deregulation. Oxidative stress-induced DNA damage, cellular apoptosis, and cellular senescence are all responsible for this tissue dysfunction and the imbalance in the bone homeostasis. These cellular mechanisms have...

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PMID: 33805567
DOI: 10.3390/ijms22073553

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