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Article

Elimination of senescent osteoclast progenitors has no effect on the age‐associated loss of bone mass in mice

17 Feb 2019

Abstract excerpt

Both an increase in osteoclast and a decrease in osteoblast numbers contribute to skeletal aging. Markers of cellular senescence, including expression of the cyclin inhibitor p16, increase with aging in several bone cell populations. The elimination of p16-expressing cells in old mice, using the INK-ATTAC transgene, increases bone mass indicating that senescent cells contribute to skeletal aging. However, the...

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PMID: 30773784
DOI: 10.1111/acel.12923

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