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Cellular senescence by loss of <i>Men1</i> in osteoblasts is critical for age‐related osteoporosis

22 Jun 2024

Abstract excerpt

Recent evidence suggests an association between age-related osteoporosis and cellular senescence in the bone; however, the specific bone cells that play a critical role in age-related osteoporosis and the mechanism remain unknown. Results revealed that age-related osteoporosis is characterized by the loss of osteoblast Men1. Osteoblast-specific inducible knockout of Men1 caused structural changes in the mice...

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PMID: 39384404
DOI: 10.1111/acel.14254

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