Loss of the Osteogenic Differentiation Potential during Senescence Is Limited to Bone Progenitor Cells and Is Dependent on p53

Abstract excerpt

DNA damage can lead to the induction of cellular senescence. In particular, we showed that exposure to ionizing radiation (IR) leads to the senescence of bone marrow-derived multipotent stromal cells (MSC) and osteoblast-like stromal cells (OB-SC), a phenotype associated with bone loss. The mechanism by which IR leads to bone dysfunction is not fully understood. One possibility involves that DNA damage-induced...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Mesenchymal stem cell research
• Share to MicroRNA in disease regulation
• Share to Telomeres, Telomerase, and Senescence