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Article

Tgfbr2 is required in osterix expressing cells for postnatal skeletal development.

Bone - 1 Apr 2017

Peters Sarah B, Wang Ying, Serra Rosa

Abstract excerpt

Transforming growth factor β (TGFβ) is known to play an important role in early skeletal development. We previously demonstrated that loss of TGFβ receptor II (Tgfbr2) in Prx1-Cre-expressing mesenchyme results in defects in long bones, joints, and the skull vault in mice resulting from reduced naïve mesenchymal proliferation and condensation that interrupted osteoblast differentiation. In contrast, others have...

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PMID: 28043895
DOI: 10.1016/j.bone.2016.12.017
PMCID: PMC5368008

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