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Article

Hypoxia-inducible factor-2α mediates senescence-associated intrinsic mechanisms of age-related bone loss.

Experimental & molecular medicine - 1 Apr 2021

Lee Sun Young, Park Ka Hyon, Lee Gyuseok, Kim Su-Jin, Song Won-Hyun, Kwon Seung-Hee, Koh Jeong-Tae, Huh Yun Hyun, Ryu Je-Hwang

Abstract excerpt

Aging is associated with cellular senescence followed by bone loss leading to bone fragility in humans. However, the regulators associated with cellular senescence in aged bones need to be identified. Hypoxia-inducible factor (HIF)-2α regulates bone remodeling via the differentiation of osteoblasts and osteoclasts. Here, we report that HIF-2α expression was highly upregulated in aged bones. HIF-2α depletion in...

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Identifiers

PMID: 33811248
DOI: 10.1038/s12276-021-00594-y
PMCID: PMC8102580

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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