Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tuberculosis resistance-conferring mutations with fitness cost among HIV-positive individuals in Uganda.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease - 1 May 2017

Ssengooba W, Lukoye D, Meehan C J, Kateete D P, Joloba M L, de Jong B C, Cobelens F G, van Leth F

Abstract excerpt

BACKGROUND: Multidrug-resistant tuberculosis (MDR-TB) is considered to be less transmissible due to the fitness cost associated with drug resistance-conferring mutations in essential genes. OBJECTIVE: To test the hypothesis that TB drug resistance-conferring mutations with fitness cost are more frequent among human immunodeficiency virus (HIV) positive than among HIV-negative patients. DESIGN: We analysed all...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antitubercular Agents
Share to Drug Resistance, Multiple, Bacterial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome, Bacterial

Share to Isoniazid

Share to Mycobacterium tuberculosis

Share to Rifampin

Share to Tuberculosis, Multidrug-Resistant

Share to Uganda

Source

Identifiers

PMID: 28399968
DOI: 10.5588/ijtld.16.0544

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tuberculosis resistance-conferring mutations with fitness cost among HIV-positive individuals in Uganda.PMID 28399968Read ↗

Drug resistance, fitness and compensatory mutations in Mycobacterium tuberculosis.Semantic proximity Read ↗

HIV Coinfection Is Associated with Low-Fitness rpoB Variants in Rifampicin-Resistant Mycobacterium tuberculosis.Semantic proximity Read ↗

Fitness Costs of Drug Resistance Mutations in Multidrug-Resistant Mycobacterium tuberculosis: A Household-Based Case-Control Study.Semantic proximity Read ↗

Patterns of compensatory mutations in rpoA/B/C genes of multidrug resistant M. tuberculosis in Uganda.Semantic proximity Read ↗

Spread of a low-fitness drug-resistant Mycobacterium tuberculosis strain in a setting of high human immunodeficiency virus prevalence.Semantic proximity Read ↗

Tuberculosis: drug resistance, fitness, and strategies for global control.Semantic proximity Read ↗

HIV coinfection is associated with low fitness <i>rpoB</i> variants in rifampicin-resistant <i>Mycobacterium tuberculosis</i>Semantic proximity Read ↗

Rifampicin Resistance: Fitness Costs and the Significance of Compensatory EvolutionSemantic proximity Read ↗

The Distribution of Fitness Costs of Resistance-Conferring Mutations Is a Key Determinant for the Future Burden of Drug-Resistant Tuberculosis: A Model-Based Analysis.Semantic proximity Read ↗

Compensatory effects of M. tuberculosis rpoB mutations outside the rifampicin resistance-determining region.Semantic proximity Read ↗

Fitness of drug resistant Mycobacterium tuberculosis and the impact on the transmission among household contacts.Semantic proximity Read ↗

Effect of rpoB mutations conferring rifampin resistance on fitness of Mycobacterium tuberculosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.