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Article

Patterns of compensatory mutations in rpoA/B/C genes of multidrug resistant M. tuberculosis in Uganda.

PloS one - 1 Jan 2025

Kateete David Patrick, Namakula Shakira, Kigozi Edgar, Katabazi Fred A, Kasule George William, Musisi Kenneth, Wampande Edward, Lukoye Deus, Joloba Moses L

Abstract excerpt

Mutations in rpoB, a gene that encodes the bacterial RNA polymerase (RNAP) beta-subunit, can cause high-level resistance to rifampicin. Approximately 95% of rifampicin-resistant Mycobacterium tuberculosis clinical isolates harbour mutations in an 81-base pair rpoB region referred to as the rifampicin-resistance-determining region (rpoB/RRDR). Also, rifampicin-resistant M. tuberculosis clinical isolates carry...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41343595
DOI: 10.1371/journal.pone.0328957
PMCID: PMC12677784

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