Article
The Distribution of Fitness Costs of Resistance-Conferring Mutations Is a Key Determinant for the Future Burden of Drug-Resistant Tuberculosis: A Model-Based Analysis.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 15 Oct 2015
Knight Gwenan M, Colijn Caroline, Shrestha Sourya, Fofana Mariam, Cobelens Frank, White Richard G, Dowdy David W, Cohen Ted
Abstract excerpt
BACKGROUND: Drug resistance poses a serious challenge for the control of tuberculosis in many settings. It is well established that the expected future trend in resistance depends on the reproductive fitness of drug-resistant Mycobacterium tuberculosis. However, the variability in fitness between strains with different resistance-conferring mutations has been largely ignored when making these predictions....
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