Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Fitness Costs of Drug Resistance Mutations in Multidrug-Resistant Mycobacterium tuberculosis: A Household-Based Case-Control Study.

The Journal of infectious diseases - 1 Jan 2016

Salvatore Phillip P, Becerra Mercedes C, Abel zur Wiesch Pia, Hinkley Trevor, Kaur Devinder, Sloutsky Alexander, Cohen Ted

Abstract excerpt

BACKGROUND: The projected long-term prevalence of multidrug-resistant (MDR) tuberculosis depends upon the relative fitness of MDR Mycobacterium tuberculosis strains, compared with non-MDR strains. While many experimental models have tested the in vitro or in vivo fitness costs of various drug resistance mutations, fewer epidemiologic studies have attempted to validate these experimental findings. METHODS: We...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Fitness
Share to Case-Control Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Multiple, Bacterial

Share to Family Characteristics

Share to Molecular Epidemiology

Share to Mycobacterium tuberculosis

Share to Tuberculosis, Multidrug-Resistant

Source

Open in PubMed Open full text

Identifiers

PMID: 26092854
DOI: 10.1093/infdis/jiv347
PMCID: PMC4676541

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Fitness Costs of Drug Resistance Mutations in Multidrug-Resistant Mycobacterium tuberculosis: A Household-Based Case-Control Study.PMID 26092854Read ↗

Tuberculosis: drug resistance, fitness, and strategies for global control.Semantic proximity Read ↗

Fitness of drug resistant Mycobacterium tuberculosis and the impact on the transmission among household contacts.Semantic proximity Read ↗

Tuberculosis resistance-conferring mutations with fitness cost among HIV-positive individuals in Uganda.Semantic proximity Read ↗

Epistasis between antibiotic resistance mutations drives the evolution of extensively drug-resistant tuberculosisSemantic proximity Read ↗

Drug resistance, fitness and compensatory mutations in Mycobacterium tuberculosis.Semantic proximity Read ↗

The Distribution of Fitness Costs of Resistance-Conferring Mutations Is a Key Determinant for the Future Burden of Drug-Resistant Tuberculosis: A Model-Based Analysis.Semantic proximity Read ↗

Genetic variation in Mycobacterium tuberculosis isolates from a London outbreak associated with isoniazid resistance.Semantic proximity Read ↗

The competitive cost of antibiotic resistance in Mycobacterium tuberculosis.Semantic proximity Read ↗

Impact of bacterial genetics on the transmission of isoniazid-resistant Mycobacterium tuberculosis.Semantic proximity Read ↗

Spread of a low-fitness drug-resistant Mycobacterium tuberculosis strain in a setting of high human immunodeficiency virus prevalence.Semantic proximity Read ↗

Quantifying transmission fitness costs of multi-drug resistant tuberculosisSemantic proximity Read ↗

The interplay between drug resistance and fitness in malaria parasitesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.