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Article

Downregulation of Plzf Gene Ameliorates Metabolic and Cardiac Traits in the Spontaneously Hypertensive Rat.

Hypertension (Dallas, Tex. : 1979) - 1 Jun 2017

Liška František, Landa Vladimír, Zídek Václav, Mlejnek Petr, Šilhavý Jan, Šimáková Miroslava, Strnad Hynek, Trnovská Jaroslava, Škop Vojtěch, Kazdová Ludmila, Starker Colby G, Voytas Daniel F, Izsvák Zsuzsanna, Mancini Massimiliano, Šeda Ondřej, Křen Vladimír, Pravenec Michal

Abstract excerpt

The spontaneously hypertensive rat (SHR), one of the most widely used model of essential hypertension, is predisposed to left ventricular hypertrophy, myocardial fibrosis, and metabolic disturbances. Recently, quantitative trait loci influencing blood pressure, left ventricular mass, and heart interstitial fibrosis were genetically isolated within a minimal congenic subline that contains only 7 genes, including...

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Share to Blood Pressure Determination
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Hypertrophy, Left Ventricular

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Identifiers

PMID: 28396530
DOI: 10.1161/HYPERTENSIONAHA.116.08798

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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