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Maternal Exposure to High-Fat Diet Induces Long-Term Derepressive Chromatin Marks in the Heart

9 Jan 2020

Abstract excerpt

Heart diseases are a leading cause of death. While the link between early exposure to nutritional excess and heart disease risk is clear, the molecular mechanisms involved are poorly understood. In the developmental programming field, increasing evidence is pointing out the critical role of epigenetic mechanisms. Among them, polycomb repressive complex 2 (PRC2) and DNA methylation play a critical role in heart...

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PMID: 31936461
DOI: 10.3390/nu12010181

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