IFN-λ3, not IFN-λ4, likely mediates IFNL3-IFNL4 haplotype-dependent hepatic inflammation and fibrosis.

doi:10.1038/ng.3836

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Article

IFN-λ3, not IFN-λ4, likely mediates IFNL3-IFNL4 haplotype-dependent hepatic inflammation and fibrosis.

Nature genetics - 1 May 2017

Eslam Mohammed, McLeod Duncan, Kelaeng Kebitsaone Simon, Mangia Alessandra, Berg Thomas, Thabet Khaled, Irving William L, Dore Gregory J, Sheridan David, Grønbæk Henning, Abate Maria Lorena, Hartmann Rune, Bugianesi Elisabetta, Spengler Ulrich, Rojas Angela, Booth David R, Weltman Martin, Mollison Lindsay, Cheng Wendy, Riordan Stephen, Mahajan Hema, Fischer Janett, Nattermann Jacob, Douglas Mark W, Liddle Christopher, Powell Elizabeth, Romero-Gomez Manuel, George Jacob

Abstract excerpt

Genetic variation in the IFNL3-IFNL4 (interferon-λ3-interferon-λ4) region is associated with hepatic inflammation and fibrosis. Whether IFN-λ3 or IFN-λ4 protein drives this association is not known. We demonstrate that hepatic inflammation, fibrosis stage, fibrosis progression rate, hepatic infiltration of immune cells, IFN-λ3 expression, and serum sCD163 levels (a marker of activated macrophages) are greater in...

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PMID: 28394349
DOI: 10.1038/ng.3836

Genes

IFNL3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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