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Interferon lambda 4 rs368234815 TT>δG variant is associated with liver damage in patients with nonalcoholic fatty liver disease.

Hepatology (Baltimore, Md.) - 1 Dec 2017

Petta Salvatore, Valenti Luca, Tuttolomondo Antonino, Dongiovanni Paola, Pipitone Rosaria Maria, Cammà Calogero, Cabibi Daniela, Di Marco Vito, Fracanzani Anna Ludovica, Badiali Sara, Nobili Valerio, Fargion Silvia, Grimaudo Stefania, Craxì Antonio

Abstract excerpt

The interferon (IFN) lambda 3/4 (IFNL3/4) locus, influencing innate immunity regulation, has been associated with the severity of hepatitis and fibrosis progression during chronic hepatitis C infection, while contrasting results were reported in nonalcoholic fatty liver disease. In this study, we examined whether rs12979860 and the linked causal rs368234815 variant encoding for the alternative IFNL4 protein...

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Source

Identifiers

PMID: 28741298
DOI: 10.1002/hep.29395

Genes

IFNL3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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