Article
IFNL3/4 genotype is associated with altered immune cell populations in peripheral blood in chronic hepatitis C infection.
Genes and immunity - 1 Sept 2016
O'Connor K S, Read S A, Wang M, Schibeci S, Eslam M, Ong A, Weltman M D, Douglas M W, Mazzola A, Craxì A, Petta S, Stewart G J, Liddle C, George J, Ahlenstiel G, Booth D R
Abstract excerpt
Single-nucleotide polymorphisms near the interferon lambda 3 (IFNL3) gene predict outcomes to infection and anti-viral treatment in hepatitis C virus (HCV) infection. To identify IFNL3 genotype effects on peripheral blood, we collected phenotype data on 400 patients with genotype 1 chronic hepatitis C (CHC). The IFNL3 responder genotype predicted significantly lower white blood cells (WBCs), as well as lower...
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