Article
Mitochondrial electron transport is a key determinant of life span in Caenorhabditis elegans.
Developmental cell - 1 Nov 2001
Feng J, Bussière F, Hekimi S
Abstract excerpt
Increased protection from reactive oxygen species (ROS) is believed to increase life span. However, it has not been clearly demonstrated that endogenous ROS production actually limits normal life span. We have identified a mutation in the Caenorhabditis elegans iron sulfur protein (isp-1) of mitochondrial complex III, which results in low oxygen consumption, decreased sensitivity to ROS, and increased life span....
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