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Article

Superoxide dismutase is dispensable for normal animal lifespan.

Proceedings of the National Academy of Sciences of the United States of America - 10 Apr 2012

Van Raamsdonk Jeremy Michael, Hekimi Siegfried

Abstract excerpt

Reactive oxygen species (ROS) are toxic oxygen-containing molecules that can damage multiple components of the cell and have been proposed to be the primary cause of aging. The antioxidant enzyme superoxide dismutase (SOD) is the only eukaryotic enzyme capable of detoxifying superoxide, one type of ROS. The fact that SOD is present in all aerobic organisms raises the question as to whether SOD is absolutely...

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Identifiers

PMID: 22451939
DOI: 10.1073/pnas.1116158109
PMCID: PMC3326508

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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