Genetic variants associated with phenytoin-related severe cutaneous adverse reactions.

doi:10.1001/jama.2014.7859

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Article

Genetic variants associated with phenytoin-related severe cutaneous adverse reactions.

JAMA - 6 Aug 2014

Chung Wen-Hung, Chang Wan-Chun, Lee Yun-Shien, Wu Ying-Ying, Yang Chih-Hsun, Ho Hsin-Chun, Chen Ming-Jing, Lin Jing-Yi, Hui Rosaline Chung-Yee, Ho Ji-Chen, Wu Wei-Ming, Chen Ting-Jui, Wu Tony, Wu Yih-Ru, Hsih Mo-Song, Tu Po-Hsun, Chang Chen-Nen, Hsu Chien-Ning, Wu Tsu-Lan, Choon Siew-Eng, Hsu Chao-Kai, Chen Der-Yuan, Liu Chin-San, Lin Ching-Yuang, Kaniwa Nahoko, Saito Yoshiro, Takahashi Yukitoshi, Nakamura Ryosuke, Azukizawa Hiroaki, Shi Yongyong, Wang Tzu-Hao, Chuang Shiow-Shuh, Tsai Shih-Feng, Chang Chee-Jen, Chang Yu-Sun, Hung Shuen-Iu

Abstract excerpt

IMPORTANCE: The antiepileptic drug phenytoin can cause cutaneous adverse reactions, ranging from maculopapular exanthema to severe cutaneous adverse reactions, which include drug reactions with eosinophilia and systemic symptoms, Stevens-Johnson syndrome, and toxic epidermal necrolysis. The pharmacogenomic basis of phenytoin-related severe cutaneous adverse reactions remains unknown. OBJECTIVE: To investigate the...

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PMID: 25096692
DOI: 10.1001/jama.2014.7859

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