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Article

HLA Alleles and CYP 2C9*3 as Predictors of Phenytoin Hypersensitivity in East Asians

30 Sept 2018

Abstract excerpt

To develop a pre-emptive genetic test that comprises multiple predisposing alleles for the prevention of phenytoin-related severe cutaneous adverse reactions (SCARs), three sets of patients with phenytoin-SCAR and drug-tolerant controls from Taiwan, Thailand, and Japan, were enrolled for this study. In addition to cytochrome P450 (CYP)2C9*3, we found that HLA-B*13:01, HLA-B*15:02, and HLA-B*51:01 were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 30270535
DOI: 10.1002/cpt.1190

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