Article
Phenobarbital-induced severe cutaneous adverse drug reactions are associated with CYP2C19*2 in Thai children.
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology - 1 May 2013
Manuyakorn Wiparat, Siripool Khanitha, Kamchaisatian Wasu, Pakakasama Samart, Visudtibhan Anannit, Vilaiyuk Soamarat, Rujirawat Thidarat, Benjaponpitak Suwat
Abstract excerpt
BACKGROUND: Aromatic anticonvulsant-induced severe cutaneous adverse drug reactions (SCARs), including Stevens-Johnson syndrome (SJS), toxic epidermal necrosis (TEN), and drug rash with eosinophilia and systemic symptoms (DRESS), are fatal immune-mediated adverse drug reactions. CYP2C19, a cytochrome P450 isoform, plays a role in metabolic rate of aromatic anticonvulsant. HLA-B*1502 has also been demonstrated to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.