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Genetic and clinical risk factors associated with phenytoin-induced cutaneous adverse drug reactions in Thai population.

Pharmacoepidemiology and drug safety - 1 May 2020

Sukasem Chonlaphat, Sririttha Suthida, Tempark Therdpong, Klaewsongkram Jettanong, Rerkpattanapipat Ticha, Puangpetch Apichaya, Boongird Apisit, Chulavatnatol Suvatna

Abstract excerpt

OBJECTIVE: This study aimed to describe the genetic and clinical risk factors associated with phenytoin-induced cutaneous adverse drug reactions (PHT-induced cADRs) in Thai patients. METHOD: A retrospective case-control study was conducted among 88 PHT- cADRs (25 SJS/TEN, 37 DRESS/DIHS and 26 MPE) compared to 70 PHT-tolerant controls during 2008-2017. Genotyping was performed by Taqman RT-PCR (EPHX1 337 T > C,...

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PMID: 32134161
DOI: 10.1002/pds.4979

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