Article
Whole transcriptome profiling of the human hippocampus suggests an involvement of the KIBRA rs17070145 polymorphism in differential activation of the MAPK signaling pathway.
Hippocampus - 1 Jul 2017
Piras Ignazio S, Krate Jonida, Schrauwen Isabelle, Corneveaux Jason J, Serrano Geidy E, Sue Lucia, Beach Thomas G, Huentelman Matthew J
Abstract excerpt
The rs17070145-T variant of the WWC1 gene, coding for the KIBRA protein, has been associated with both increased episodic memory performance and lowered risk for late onset Alzheimer's disease, although the mechanism behind this protective effect has not been completely elucidated. To achieve a better understanding of the pathways modulated by rs17070145 and its associated functional variant(s), we used laser...
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