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Article

Genetic signature of human longevity in PKC and NF-κB signaling.

Aging cell - 1 Jul 2021

Ryu Seungjin, Han Jeehae, Norden-Krichmar Trina M, Zhang Quanwei, Lee Seunggeun, Zhang Zhengdong, Atzmon Gil, Niedernhofer Laura J, Robbins Paul D, Barzilai Nir, Schork Nicholas J, Suh Yousin

Abstract excerpt

Gene variants associated with longevity are also associated with protection against cognitive decline, dementia and Alzheimer's disease, suggesting that common physiologic pathways act at the interface of longevity and cognitive function. To test the hypothesis that variants in genes implicated in cognitive function may promote exceptional longevity, we performed a comprehensive 3-stage study to identify...

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Identifiers

PMID: 34197020
DOI: 10.1111/acel.13362
PMCID: PMC8282271

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CLU
NFKBIA
PRKCH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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