Article

DDR1-WWC1 complex is associated with human cognition

2025-05-09

Abstract excerpt

The WWC1 ( KIBRA ) gene has been repeatedly implicated in cognitive performance, with carriers of the favorable allele showing enhanced episodic memory, spatial ability, and achievements in chess and STEM fields. However, gene-level associations do not reveal the underlying biological mechanisms. Here, we applied a modern proteomic assay coupled with an AI-based protein complex quantification method to elucidate...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 40e5eb14-345a-50ed-96f4-66d0a927b2ef
DOI: 10.12688/f1000research.163208.1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

DDR1-WWC1 complex is associated with human cognitionDOI 10.12688/f1000research.163208.1Read

Identification of a common variant affecting human episodic memory performance using a pooled genome-wide association approach: a case study of disease gene identification.Semantic proximity Read

Whole transcriptome profiling of the human hippocampus suggests an involvement of the KIBRA rs17070145 polymorphism in differential activation of the MAPK signaling pathway.Semantic proximity Read

Association of KIBRA with episodic and working memory: a meta-analysis.Semantic proximity Read

Common exonic missense variants in the C2 domain of the human KIBRA protein modify lipid binding and cognitive performance.Semantic proximity Read

KIBRA Gene Variant Is Associated with Ability in Chess and Science.Semantic proximity Read

Werner SyndromeSemantic proximity Read

Changes in protein function underlies the disease spectrum in patients with CHIP mutationsSemantic proximity Read

Genome-wide association study identifies novel loci for plasma levels of protein C: the ARIC study.Semantic proximity Read

Distinctive phosphoinositide- and Ca2+-binding properties of normal and cognitive performance-linked variant forms of KIBRA C2 domain.Semantic proximity Read

A genome-wide association study of cognitive function in Chinese adult twins.Semantic proximity Read

Polygenic proxies of age-related plasma protein levels reveal TIMP2 role in cognitive performanceSemantic proximity Read

PICK1 Genetic Variation and Cognitive Function in Patients with Schizophrenia.Semantic proximity Read