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Genome‐wide transcriptome analysis identifies novel dysregulated genes implicated in Alzheimer's pathology

5 Aug 2020

Abstract excerpt

Abstract Introduction Abnormal gene expression patterns may contribute to the onset and progression of late‐onset Alzheimer's disease (LOAD). Methods We performed transcriptome‐wide meta‐analysis (N = 1440) of blood‐based microarray gene expression profiles as well as neuroimaging and cerebrospinal fluid (CSF) endophenotype analysis. Results We identified and replicated five genes (CREB5, CD46, TMBIM6, IRAK3, and...

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PMID: 32755048
DOI: 10.1002/alz.12092

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