Article
Association of common KIBRA variants with episodic memory and AD risk.
Neurobiology of aging - 1 Mar 2011
Burgess Jeremy D, Pedraza Otto, Graff-Radford Neill R, Hirpa Meron, Zou Fanggeng, Miles Richard, Nguyen Thuy, Li Ma, Lucas John A, Ivnik Robert J, Crook Julia, Pankratz V Shane, Dickson Dennis W, Petersen Ronald C, Younkin Steven G, Ertekin-Taner Nilüfer
Abstract excerpt
KIBRA single nucleotide polymorphism (SNP) rs17070145 was identified in a genome-wide association study (GWAS) of memory performance, with some but not all follow-up studies confirming association of its T allele with enhanced memory. This allele was associated with reduced Alzheimer's disease (AD) risk in 1 study, which also found overexpression of KIBRA in memory-related brain regions of AD. We genotyped...
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