Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The dominant role of proofreading exonuclease activity of replicative polymerase ε in cellular tolerance to cytarabine (Ara-C).

Oncotarget - 16 May 2017

Tsuda Masataka, Terada Kazuhiro, Ooka Masato, Kobayashi Koji, Sasanuma Hiroyuki, Fujisawa Ryo, Tsurimoto Toshiki, Yamamoto Junpei, Iwai Shigenori, Kadoda Kei, Akagawa Remi, Huang Shar-Yin Naomi, Pommier Yves, Sale Julian E, Takeda Shunichi, Hirota Kouji

Abstract excerpt

Chemotherapeutic nucleoside analogs, such as Ara-C, 5-Fluorouracil (5-FU) and Trifluridine (FTD), are frequently incorporated into DNA by the replicative DNA polymerases. However, it remains unclear how this incorporation kills cycling cells. There are two possibilities: Nucleoside analog triphosphates inhibit the replicative DNA polymerases, and/or nucleotide analogs mis-incorporated into genomic DNA interfere...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antimetabolites, Antineoplastic
Share to Cell Cycle

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytarabine

Share to DNA Polymerase II

Share to DNA Replication

Share to Drug Tolerance

Share to Gene Knockout Techniques

Share to Ubiquitin-Protein Ligases

Source

Open in PubMed Open full text

Identifiers

PMID: 28380422
DOI: 10.18632/oncotarget.16508
PMCID: PMC5464882

Genes

RAD18

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The dominant role of proofreading exonuclease activity of replicative polymerase ε in cellular tolerance to cytarabine (Ara-C).PMID 28380422Read ↗

Dual roles for DNA polymerase eta in homologous DNA recombination and translesion DNA synthesis.Semantic proximity Read ↗

CTF18-RFC contributes to cellular tolerance against chain-terminating nucleoside analogs (CTNAs) in cooperation with proofreading exonuclease activity of DNA polymerase εSemantic proximity Read ↗

DNA replication stress induced by trifluridine determines tumor cell fate according to p53 statusSemantic proximity Read ↗

Replication past O(6)-methylguanine by yeast and human DNA polymerase eta.Semantic proximity Read ↗

A Role for Yeast and Human Translesion Synthesis DNA Polymerases in Promoting Replication through 3-Methyl AdenineSemantic proximity Read ↗

Effect of the Thymidylate Synthase Inhibitors on dUTP and TTP Pool Levels and the Activities of DNA Repair Glycosylases on Uracil and 5-Fluorouracil in DNASemantic proximity Read ↗

Specificity of mutations induced by incorporation of oxidized dNTPs into DNA by human DNA polymerase eta.Semantic proximity Read ↗

DNA polymerase iota-dependent translesion replication of uracil containing cyclobutane pyrimidine dimers.Semantic proximity Read ↗

Enhanced cytarabine-induced killing in OGG1-deficient acute myeloid leukemia cellsSemantic proximity Read ↗

In vivo evidence for translesion synthesis by the replicative DNA polymerase δ.Semantic proximity Read ↗

Abacavir, an anti–HIV-1 drug, targets TDP1-deficient adult T cell leukemiaSemantic proximity Read ↗

DNA polymerases nu and theta are required for efficient immunoglobulin V gene diversification in chicken.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.