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Abacavir, an anti–HIV-1 drug, targets TDP1-deficient adult T cell leukemia

3 Apr 2015

Abstract excerpt

Adult T cell leukemia (ATL) is an aggressive T cell malignancy caused by human T cell leukemia virus type 1 (HTLV-1) and has a poor prognosis. We analyzed the cytotoxic effects of various nucleoside analog reverse transcriptase inhibitors (NRTIs) for HIV-1 on ATL cells and found that abacavir potently and selectively kills ATL cells. Although NRTIs have minimal genotoxicities on host cells, the therapeutic...

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PMID: 26601161
DOI: 10.1126/sciadv.1400203

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