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Enhanced cytarabine-induced killing in OGG1-deficient acute myeloid leukemia cells

8 Mar 2021

Abstract excerpt

expression, which correlate with increased therapeutic-induced cell cytotoxicity and good prognosis for improved, relapse-free survival compared with other AML patients. Here we present data demonstrating that AML cell lines deficient in OGG1 have enhanced sensitivity to cytarabine (cytosine arabinoside [Ara-C]) relative to OGG1-proficient cells. This enhanced cytotoxicity correlated with endogenous...

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PMID: 33836581
DOI: 10.1073/pnas.2016833118

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