Article
In vivo evidence for translesion synthesis by the replicative DNA polymerase δ.
Nucleic acids research - 6 Sept 2016
Hirota Kouji, Tsuda Masataka, Mohiuddin, Tsurimoto Toshiki, Cohen Isadora S, Livneh Zvi, Kobayashi Kaori, Narita Takeo, Nishihara Kana, Murai Junko, Iwai Shigenori, Guilbaud Guillaume, Sale Julian E, Takeda Shunichi
Abstract excerpt
The intolerance of DNA polymerase δ (Polδ) to incorrect base pairing contributes to its extremely high accuracy during replication, but is believed to inhibit translesion synthesis (TLS). However, chicken DT40 cells lacking the POLD3 subunit of Polδ are deficient in TLS. Previous genetic and biochemical analysis showed that POLD3 may promote lesion bypass by Polδ itself independently of the translesion polymerase...
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