Article
An APE1 inhibitor reveals critical roles of the redox function of APE1 in KSHV replication and pathogenic phenotypes.
PLoS pathogens - 1 Apr 2017
Zhong Canrong, Xu Mengyang, Wang Yan, Xu Jun, Yuan Yan
Abstract excerpt
APE1 is a multifunctional protein with a DNA base excision repair function in its C-terminal domain and a redox activity in its N-terminal domain. The redox function of APE1 converts certain transcription factors from inactive oxidized to active reduced forms. Given that among the APE1-regulated transcription factors many are critical for KSHV replication and pathogenesis, we investigated whether inhibition of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.