Article

Redox Activity of APE1 Mediates SASP Suppression in Senescent Fibroblasts

2025-06-11

Abstract excerpt

<title>Abstract</title> <p>Cellular senescence, triggered by multiple stressors, was characterized by senescence-associated secretory phenotype (SASP) that drive age-related pathologies. Apurinic apyrimidinic endonuclease 1 (APE1), a bifunctional enzyme with redox and DNA repair activities, regulates inflammation and senescence, but its role in SASP expression remains unclear. This study aimed to elucidate how AP...

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Literature Corpus work: 67495636-ed08-5f0f-9bc8-9a0573efb8ff
DOI: 10.21203/rs.3.rs-6841207/v1

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