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Anticancer clinical utility of the apurinic/apyrimidinic endonuclease/redox factor-1 (APE/Ref-1).

Chinese journal of cancer - 1 Mar 2010

Zhang Ying, Wang Jian

Abstract excerpt

Apurinic/apyrimidinic endonuclease/redox factor-1 (APE/Ref-1), as a type of multifunctional protein, plays an essential role in the base excision repair (BER) pathway, which is responsible for the repair of DNA caused by oxidative and alkylation damage. As importantly, APE/Ref-1 also functions as a redox factor maintaining transcription factors in an active reduced state. APE/Ref-1 stimulates the DNA-binding...

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Apoptosis
DNA-(Apurinic or Apyrimidinic Site) Lyase
DNA Repair
Drug Delivery Systems
Drug Resistance, Neoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Oxidation-Reduction

Precancerous Conditions

Radiation Tolerance

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Identifiers

PMID: 20193121
DOI: 10.5732/cjc.009.10285

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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