Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

APE1/Ref-1 Role in Inflammation and Immune Response

28 Feb 2022

Abstract excerpt

Apurinic/apyrimidinic endonuclease 1/redox effector factor 1 (APE1/Ref-1) is a multifunctional enzyme that is essential for maintaining cellular homeostasis. APE1 is the major apurinic/apyrimidinic endonuclease in the base excision repair pathway and acts as a redox-dependent regulator of several transcription factors, including NF-κB, AP-1, HIF-1α, and STAT3. These functions render APE1 vital to regulating cell...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Polyomavirus and related diseases
Share to DNA Repair Mechanisms
Share to Genomics, phytochemicals, and oxidative stress

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35296074
DOI: 10.3389/fimmu.2022.793096

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

APE1/Ref-1 Role in Inflammation and Immune ResponsePMID 35296074Read ↗

Anticancer clinical utility of the apurinic/apyrimidinic endonuclease/redox factor-1 (APE/Ref-1).Semantic proximity Read ↗

Exploiting the Ref-1-APE1 node in cancer signaling and other diseases: from bench to clinicSemantic proximity Read ↗

A review on protein–protein interaction network of APE1/Ref‐1 and its associated biological functionsSemantic proximity Read ↗

From DNA Repair to Redox Signaling: The Multifaceted Role of APEX1 (Apurinic/Apyrimidinic Endonuclease 1) in Cardiovascular Health and DiseaseSemantic proximity Read ↗

Redox Activity of APE1 Mediates SASP Suppression in Senescent FibroblastsSemantic proximity Read ↗

Human Apurinic/Apyrimidinic Endonuclease 1Semantic proximity Read ↗

Apurinic endonuclease-1 preserves neural genome integrity to maintain homeostasis and thermoregulation and prevent brain tumorsSemantic proximity Read ↗

APE1/Ref-1 – One Target with Multiple Indications: Emerging Aspects and New DirectionsSemantic proximity Read ↗

Essential role for mammalian apurinic/apyrimidinic (AP) endonuclease Ape1/Ref-1 in telomere maintenanceSemantic proximity Read ↗

SIRT1 gene expression upon genotoxic damage is regulated by APE1 through nCaRE-promoter elementsSemantic proximity Read ↗

An APE1 inhibitor reveals critical roles of the redox function of APE1 in KSHV replication and pathogenic phenotypes.Semantic proximity Read ↗

Functional characterization of a promoter polymorphism in APE1/Ref-1 that contributes to reduced lung cancer susceptibility.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.