Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Exploiting the Ref-1-APE1 node in cancer signaling and other diseases: from bench to clinic

31 May 2017

Abstract excerpt

Reduction-oxidation factor 1-apurinic/apyrimidinic endonuclease (Ref-1/APE1) is a critical node in tumor cells, both as a redox regulator of transcription factor activation and as part of the DNA damage response. As a redox signaling protein, Ref-1/APE1 enhances the transcriptional activity of STAT3, HIF-1α, nuclear factor kappa B, and other transcription factors to promote growth, migration, and survival in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Lymphoblastic Leukemia research
Share to DNA Repair Mechanisms
Share to Genomics, phytochemicals, and oxidative stress

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28825044
DOI: 10.1038/s41698-017-0023-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Exploiting the Ref-1-APE1 node in cancer signaling and other diseases: from bench to clinicPMID 28825044Read ↗

Anticancer clinical utility of the apurinic/apyrimidinic endonuclease/redox factor-1 (APE/Ref-1).Semantic proximity Read ↗

APE1/Ref-1 Role in Inflammation and Immune ResponseSemantic proximity Read ↗

New Ref-1/APE1 targeted inhibitors demonstrating improved potency for clinical applications in multiple cancer typesSemantic proximity Read ↗

APE1/Ref-1 – One Target with Multiple Indications: Emerging Aspects and New DirectionsSemantic proximity Read ↗

A review on protein–protein interaction network of APE1/Ref‐1 and its associated biological functionsSemantic proximity Read ↗

APE 1/Ref‐1 knockdown in pancreatic ductal adenocarcinoma – characterizing gene expression changes and identifying novel pathways using single‐cell RNA sequencingSemantic proximity Read ↗

The inhibitor of the redox activity of APE1/REF-1, APX2009, reduces the malignant phenotype of breast cancer cells.Semantic proximity Read ↗

Functional characterization of a promoter polymorphism in APE1/Ref-1 that contributes to reduced lung cancer susceptibility.Semantic proximity Read ↗

Integrated Post-Translational Modification (PTM) Proteomics Reveals Early Redox and Mitochondrial Remodeling Following Ref-1 Inhibition in Pancreatic CancerSemantic proximity Read ↗

From DNA Repair to Redox Signaling: The Multifaceted Role of APEX1 (Apurinic/Apyrimidinic Endonuclease 1) in Cardiovascular Health and DiseaseSemantic proximity Read ↗

The DNA base excision repair protein Ape1/Ref-1 as a therapeutic and chemopreventive targetSemantic proximity Read ↗

Redox Activity of APE1 Mediates SASP Suppression in Senescent FibroblastsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.