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Article

Roles of Leu28 side chain intercalation in the interaction between Cren7 and DNA.

The Biochemical journal - 9 May 2017

Zhang Zhenfeng, Zhao Mohan, Wang Li, Chen Yuanyuan, Dong Yuhui, Gong Yong, Huang Li

Abstract excerpt

Crenarchaeal chromatin protein Cren7 binds double-stranded DNA in the minor groove, introducing a sharp single-step DNA kink. The side chain of Leu28, a residue conserved among all Cren7 homologs, intercalates into the kinked DNA step. In the present study, we replaced Leu28 with a residue containing a hydrophobic side chain of different sizes (i.e. L28A, L28V, L28I, L28M and L28F). Both the stability of the...

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Identifiers

PMID: 28377493
DOI: 10.1042/BCJ20170036

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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