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Article

The conserved asparagine in the HNH motif serves an important structural role in metal finger endonucleases.

Journal of molecular biology - 4 May 2007

Huang Hsinchin, Yuan Hanna S

Abstract excerpt

The HNH motif is a small nucleic acid binding and cleavage module, widespread in metal finger endonucleases in all life kingdoms. Here we studied a non-specific endonuclease, the nuclease domain of ColE7 (N-ColE7), to decipher the role of the conserved asparagine and histidine residues in the HNH motif. We found, using fluorescence resonance energy transfer (FRET) assays, that the DNA hydrolysis activity of H545...

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Identifiers

PMID: 17368670
DOI: 10.1016/j.jmb.2007.02.044

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The conserved asparagine in the HNH motif serves an important structural role in metal finger endonucleases.PMID 17368670Read ↗

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