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Article

Mutations in the alpha8 loop of human APE1 alter binding and cleavage of DNA containing an abasic site.

The Journal of biological chemistry - 21 Nov 2003

Shen Jiang-Cheng, Loeb Lawrence A

Abstract excerpt

Recent crystallographic studies reveal loops in human AP endonuclease 1 (APE1) that interact with the major and minor grooves of DNA containing apurinic/apyrimidinic (AP) sites. These loops are postulated to stabilize the DNA helix and the flipped out AP residue. The loop alpha8 interacts with the major groove on the 3' side of the AP site. To determine the essentiality of the amino acids that constitute the...

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Identifiers

PMID: 12966083
DOI: 10.1074/jbc.M309362200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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