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Article

Structure of a Leu3-DNA complex: recognition of everted CGG half-sites by a Zn2Cys6 binuclear cluster protein.

Structure (London, England : 1993) - 1 Apr 2006

Fitzgerald Mary X, Rojas Jeannie R, Kim John M, Kohlhaw Gunter B, Marmorstein Ronen

Abstract excerpt

Gal4 is the prototypical Zn2Cys6 binuclear cluster transcriptional regulator that binds as a homodimer to DNA containing inverted CGG half-sites. Leu3, a member of this protein family, binds to everted (opposite polarity to inverted) CGG half-sites, and an H50C mutation within the Leu3 Zn2Cys6 binuclear motif abolishes its transcriptional repression function without impairing DNA binding. We report the X-ray...

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PMID: 16615914
DOI: 10.1016/j.str.2005.11.025

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