Article
Spatial analysis reveals the evolving organization of IDH-mutant glioma.
Cancer cell - 14 Sept 2026
Hoefflin Rouven, Greenwald Alissa C, Galili Darnell Noam, Mount Christopher W, Tiomkin Yali, Gonzalez Castro L Nicolas, Wen Zebin, Simkin Dor, Patterson Angelica B, Goliand Inna, Golani Ofra, Fellus-Alyagor Liat, Cohen Marina, Joseph Kevin, Beck Jürgen, Ravi Vidhya M, Kedmi Merav, Keren-Shaul Hadas, Weller Michael, Addadi Yoseph, Neidert Marian C, Suvà Mario L, Tirosh Itay
Abstract excerpt
Adult diffuse gliomas are composed of malignant cell states interwoven with the non-malignant brain microenvironment. Here, we combine spatial transcriptomics and spatial proteomics of isocitrate dehydrogenase (IDH)-mutant gliomas to define organizational principles across histological grades. In low-grade tumors, spatial organization is shaped by underlying brain anatomy. We identify a functional white-gray...
Read the complete abstract on PubMedTopics
- Isocitrate Dehydrogenase
- Glioma
- Humans
- Brain Neoplasms
- Mutation