Article

Multi◻region whole◻genome and transcriptomic profiling uncovers plastic, subclone◻linked cell states in high◻grade diffuse astrocytomas

2026-08-11

Abstract excerpt

Intratumoral heterogeneity is a defining feature of high-grade astrocytomas and a major contributor to treatment resistance. Yet how genomic diversification intersects with transcriptional plasticity remains incompletely understood. We performed high-resolution multi-omic profiling of three complex, treatment-naïve tumors (two IDH-wildtype glioblastomas and one IDH-mutant grade 4 astrocytoma). By integrating whole...

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Literature Corpus work: 01d7c1a0-b3b9-51cd-a97a-7792dc8faee3
DOI: 10.64898/2026.08.11.743949

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