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Article

Mrc1 and DNA polymerase epsilon function together in linking DNA replication and the S phase checkpoint.

Molecular cell - 10 Oct 2008

Lou Huiqiang, Komata Makiko, Katou Yuki, Guan Zhiyun, Reis Clara C, Budd Martin, Shirahige Katsuhiko, Campbell Judith L

Abstract excerpt

Yeast Mrc1, ortholog of metazoan Claspin, is both a central component of normal DNA replication forks and a mediator of the S phase checkpoint. We report that Mrc1 interacts with Pol2, the catalytic subunit of DNA polymerase epsilon, essential for leading-strand DNA replication and for the checkpoint. In unperturbed cells, Mrc1 interacts independently with both the N-terminal and C-terminal halves of Pol2 (Pol2N...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18851837
DOI: 10.1016/j.molcel.2008.08.020
PMCID: PMC2699584

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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