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Article

Checkpoint-Independent Regulation of Origin Firing by Mrc1 through Interaction with Hsk1 Kinase.

Molecular and cellular biology - 1 Apr 2017

Matsumoto Seiji, Kanoh Yutaka, Shimmoto Michie, Hayano Motoshi, Ueda Kyosuke, Fukatsu Rino, Kakusho Naoko, Masai Hisao

Abstract excerpt

Mrc1 is a conserved checkpoint mediator protein that transduces the replication stress signal to the downstream effector kinase. The loss of mrc1 checkpoint activity results in the aberrant activation of late/dormant origins in the presence of hydroxyurea. Mrc1 was also suggested to regulate orders of early origin firing in a checkpoint-independent manner, but its mechanism was unknown. Here we identify HBS (Hsk1...

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Identifiers

PMID: 28069740
DOI: 10.1128/MCB.00355-16
PMCID: PMC5359423

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