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Article

Migration of mitochondrial DNA in the nuclear genome of colorectal adenocarcinoma.

Genome medicine - 29 Mar 2017

Srinivasainagendra Vinodh, Sandel Michael W, Singh Bhupendra, Sundaresan Aishwarya, Mooga Ved P, Bajpai Prachi, Tiwari Hemant K, Singh Keshav K

Abstract excerpt

BACKGROUND: Colorectal adenocarcinomas are characterized by abnormal mitochondrial DNA (mtDNA) copy number and genomic instability, but a molecular interaction between mitochondrial and nuclear genome remains unknown. Here we report the discovery of increased copies of nuclear mtDNA (NUMT) in colorectal adenocarcinomas, which supports link between mtDNA and genomic instability in the nucleus. We name this...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28356157
DOI: 10.1186/s13073-017-0420-6
PMCID: PMC5370490

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