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Article

Mitochondrial genome instability in colorectal adenoma and adenocarcinoma.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Nov 2015

de Araujo Luiza F, Fonseca Aline S, Muys Bruna R, Plaça Jessica R, Bueno Rafaela B L, Lorenzi Julio C C, Santos Anemari R D, Molfetta Greice A, Zanette Dalila L, Souza Jorge E S, Valente Valeria, Silva Wilson A

Abstract excerpt

Mitochondrial dysfunction is regarded as a hallmark of cancer progression. In the current study, we evaluated mitochondrial genome instability and copy number in colorectal cancer using Next Generation Sequencing approach and qPCR, respectively. The results revealed higher levels of heteroplasmy and depletion of the relative mtDNA copy number in colorectal adenocarcinoma. Adenocarcinoma samples also presented an...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26069104
DOI: 10.1007/s13277-015-3640-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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