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Estrogen receptor-alpha gene XbaI A > G polymorphism influences short-term cognitive decline in healthy oldest-old individuals.

Arquivos de neuro-psiquiatria - 1 Mar 2017

Chaves Amanda Caroline Silva, Fraga Vanessa Gomes, Guimarães Henrique Cerqueira, Teixeira Antonio Lucio, Barbosa Maira Tonidandel, Carvalho Maria das Graças, Mota Ana Paula Lucas, Silva Ieda de Fátima Oliveira, Caramelli Paulo, Gomes Karina Braga, Alpoim Patrícia Nessralla

Abstract excerpt

METHODS: The individuals were categorized in two groups according to the presence or absence of cognitive decline. Cognitive data were related to genetic information. RESULTS: The XbaI -351 AA genotype was more common among cognitive decliners, while -351G allele carriers showed cognitive stability or improvement. CONCLUSION: These results suggest that ESR-1 could be associated with one-year cognitive decline in...

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PMID: 28355325
DOI: 10.1590/0004-282X20170018

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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